Intercalative binding to DNA of antitumour drugs derived from 3-nitro-1,8-naphthalic acid
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چکیده
منابع مشابه
Intercalative binding to DNA of antitumour drugs derived from 3-nitro- 1, 8-naphthalic acid
Two new antitumour drugs, imide derivatives of 3-nitro-1,8-naphthalic acid having different basic side chains linked to the imide nitrogen, have been shown to bind to double-helical DNA by intercalation. At ionic strength 0.01 mol/litre, pH 7, their intrinsic association constants are about 1.45 x 10(5) M-1 and each bound ligand molecule occludes about 3.4 nucleotides of the DNA lattice. They r...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1979
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/7.1.217